Metabolic control analysis in a nutshell

Metabolic control analysis is a powerful quantitative framework for understanding the relationship between the steady-state properties of a (bio)chemical reaction network as a whole and the properties of its component reactions. Although in essence it is a typical sensitivity analysis of a dynamical system, the stoichiometric structure of reaction networks gives it a character of its own. It has proved very useful for both theoretical and experimental analysis of cellular systems, leading to deep insights into matters of control and regulation. This paper attempts to capture in a nutshell the detailed derivation from first principles of all of the important theorems of control analysis starting with the general kinetic model of a reaction network.